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Dangers of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant utilization of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may possibly cause a rise in tramadol plasma levels and a lessen within the amounts of the Lively metabolite, M1.Actual physical dependenc